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Organic Chemistry 2 | Notes for Chapter 17 & 18: Aromatic Compounds & Aromatic Substitution Reactions | Klein 4th Edition

Mar 18, 2025
1 min read

For these 2 chapters, they relate to the complexity and nature of aromatic compounds and the various reactions that occur with them.

A short note regarding some weird reactions that occur is the Benzylic carbon oxidation with KMnO4 and other strong oxidants is the formating of carboxylic acids (with the cleavage of alkyl groups), where there is no online source for a potential mechanism. The closest mechanism that I could hypothesize was something similar to a Dihydroxylation and NAD+ oxidation mechanism. Another note is the director aspect of substituents on aromatic rings; master resonance reasoning and you will excel in these reactions, as all of it is purely resonance-based.


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